Buddies Pepper Lewis (Woody Harrelson) and Sonny Gilstrap (Kiefer Sutherland) who are championship rodeo partners travel to New York to find their missing friend, Nacho Salazar Joaquín Martínez after he disappears in New York City to pick up his daughter, Theresa (Cara Buono). When Pepper and Sonny find that neither is anywhere to be found, they go about the wacky adventure of finding Nacho and Theresa, and in the process, test the foundation of their friendship. Along the way, they find...

The story centers on Veronika, a woman in her mid twenties who appears to have everything: good looks, good job and a great life ahead of her. Yet she decides to end her own life. She is unsuccessful and awakens in a mental hospital where she learns that she a short time to live. However in the hospital she meets people who are only 'insane' because they don't always follow society's rules. With little left to lose, Veronika embarks on a journey on which she frees herself to experience...